Research Associate II

Software Guidance & Assistance, Inc., (SGA), is searching for a Research Associate II for a contract assignment with one of our premier Pharmaceutical services clients in South San Francisco, CA.

Responsibilities :
We are seeking a highly motivated contractor to support discovery efforts in the Macrocycle Discovery Group within the Peptide Therapeutics Department. The successful candidate will contribute to the identification of novel macrocyclic peptides using in vitro selection platforms and will play a key role in assay development, high-throughput screening, and data analysis for early drug discovery programs.

• Conduct in vitro selection campaigns using mRNA and/or phage display technologies to discover active macrocyclic peptides targeting high-priority therapeutic proteins.
• Handle phage libraries, including amplification, titration, panning, and rescue procedures.
• Design and execute ELISA-based binding assays for hit validation and screening.
• Utilize laboratory automation and high-throughput screening (HTS) techniques to enable efficient assay setup, sample processing, and reagent preparation.
• Analyze next-generation sequencing (NGS) results using internal bioinformatics tools to identify early hits and guide selection campaign progression.
• Test the incorporation and expression of non-canonical amino acid monomers to enhance library diversity through genetic code expansion.
• Maintain and manage complex reagent inventories used across multiple preclinical discovery platforms.
• Collaborate cross-functionally with scientists in biochemistry, screening, and informatics to support project goals and timelines.

Required Skills:

• B.S., M.S., or equivalent degree in Biochemistry, Molecular Biology, Chemical Biology, or a related discipline with relevant lab-based experience.
• Hands-on experience with in vitro display technologies, particularly mRNA display and/or phage display (including phage propagation and selection).
• Proficiency in ELISA, western blot, and high-throughput screening methods.
• Familiarity with NGS data analysis and experience with laboratory automation platforms.
• Strong attention to detail, excellent organizational skills, and ability to work both independently and as part of a collaborative team.

SGA is a technology and resource solutions provider driven to stand out. We are a women-owned business. Our mission: to solve big IT problems with a more personal, boutique approach. Each year, we match consultants like you to more than 1,000 engagements. When we say let's work better together, we mean it. You'll join a diverse team built on these core values: customer service, employee development, and quality and integrity in everything we do. Be yourself, love what you do and find your passion at work. Please find us at .

SGA is an Equal Opportunity Employer and does not discriminate on the basis of Race, Color, Sex, Sexual Orientation, Gender Identity, Religion, National Origin, Disability, Veteran Status, Age, Marital Status, Pregnancy, Genetic Information, or Other Legally Protected Status. We are committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, and our services, programs, and activities. Please visit our company to request an accommodation or assistance regarding our policy.