Overview
On Site
USD 64,600.00 - 107,600.00 per year
Full Time
Skills
Research and development
Assays
Data Analysis
Mass spectrometry
Mathematical modeling
Health care
Recruiting
Biochemistry
Research
DNA
Screening
Leadership
Testing
Database
Data
SAR
Presentations
Evaluation
Communication
Pharmaceutics
Payments
Legal
Law
Interviewing
Immigration
Job Details
ROLE SUMMARY
The Biochemistry Department of Pfizer Oncology Research in La Jolla, CA is seeking a full time scientist to join our drug discovery team.
The enzymologist/biochemist will make important contributions to the discovery and pre-clinical development of oncology therapeutics, and will contribute to our molecular and biochemical understanding of enzymes that mediate epigenetic modifications of histone proteins and DNA. The scientist will be actively engaged in drug discovery activities for modulators of epigenetic targets, including the characterization of epigenetic enzymes and their inhibitors as well as histone and DNA methylation profiling and selectivity screening. In particular, the biochemist will be responsible for the development and validation of robust, reproducible plate-based enzyme assays. This will include kinetic and mechanistic studies to characterize enzyme targets, biochemical pathways, and mechanism of action of lead compounds.
The candidate will be responsible for testing compounds in biochemical assays, data analysis, and proper database publication of data. The candidate will participate on project teams, providing insight and technical expertise required for project progression. The individual will work closely with cell biologists and medicinal chemists, and apply strong biochemistry knowledge/skills to oncology small molecule drug discovery and development of innovative therapies.
ROLE RESPONSIBILITIES
A successful candidate will be required to develop and execute kinetic and mechanistic enzyme assays to understand epigenetic protein targets, their function and regulation, along with determining mechanism and binding site location of inhibitors, and protein/ligand SAR. The candidate will also be responsible for the development and performance of robust, automated biochemical assays for support of a cancer epigenetic drug discovery platform.
Participation on multi-disciplinary project teams, including oral presentation of results, and contribution to the understanding of the biochemical pathways associated with tumor epigenetic changes associated with tumor development and progression is also expected.
QUALIFICATIONS
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development
The Biochemistry Department of Pfizer Oncology Research in La Jolla, CA is seeking a full time scientist to join our drug discovery team.
The enzymologist/biochemist will make important contributions to the discovery and pre-clinical development of oncology therapeutics, and will contribute to our molecular and biochemical understanding of enzymes that mediate epigenetic modifications of histone proteins and DNA. The scientist will be actively engaged in drug discovery activities for modulators of epigenetic targets, including the characterization of epigenetic enzymes and their inhibitors as well as histone and DNA methylation profiling and selectivity screening. In particular, the biochemist will be responsible for the development and validation of robust, reproducible plate-based enzyme assays. This will include kinetic and mechanistic studies to characterize enzyme targets, biochemical pathways, and mechanism of action of lead compounds.
The candidate will be responsible for testing compounds in biochemical assays, data analysis, and proper database publication of data. The candidate will participate on project teams, providing insight and technical expertise required for project progression. The individual will work closely with cell biologists and medicinal chemists, and apply strong biochemistry knowledge/skills to oncology small molecule drug discovery and development of innovative therapies.
ROLE RESPONSIBILITIES
A successful candidate will be required to develop and execute kinetic and mechanistic enzyme assays to understand epigenetic protein targets, their function and regulation, along with determining mechanism and binding site location of inhibitors, and protein/ligand SAR. The candidate will also be responsible for the development and performance of robust, automated biochemical assays for support of a cancer epigenetic drug discovery platform.
Participation on multi-disciplinary project teams, including oral presentation of results, and contribution to the understanding of the biochemical pathways associated with tumor epigenetic changes associated with tumor development and progression is also expected.
QUALIFICATIONS
- BS/MS Enzymologist/Biochemist with two or more years of experience in understanding the enzymes and proteins associated with cancer epigenetics.
- Experience in the development of assays and bioanalytical methods for studying enzyme activity and mechanism and for evaluating inhibitor potency and mechanism.
- Must have strong technical abilities; be skilled in the biochemical evaluation of enzymes including enzyme kinetics and in the development of automated plate-based biochemical assays.
- Strong interpersonal and communication skills required.
- Preference given to candidates with pharmaceutical/biotech drug discovery experience in evaluating small-molecule inhibitors against epigenetic enzyme targets such as histone methyltransferase or histone deacetylases and candidates with experience in Mass Spectrometry.
- Must be able to work at a lab bench.
- Work with standard radioactive materials (3H, 32P, etc).
- Experience in enzyme kinetics and mathematical modeling strongly preferred.
- Work Location Assignment: On Premise
- Eligible for Employee Referral
- Last Day to Apply: May 21, 2024
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development