Principal Scientist, Cryo-EM

Description

Johnson & Johnson is recruiting for a Principal Scientist, Cryo-EM, located in Spring House, PA.

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at

The Discovery Technologies and Molecular Pharmacology group is a dynamic, diverse and critical part of the Discovery Sciences organization in Janssen R&D. We are committed to the discovery and characterization of high-quality chemical leads needed for the generation of small molecule clinical compounds in all five Janssen Therapeutic Areas. This mission requires deep scientific expertise across broad disciplines including chemistry, cellular and molecular pharmacology, enzymology, screening, protein science, and structural biology coupled with an ability to work collaboratively with internal and external partners. Building on a strong legacy of success, we are currently seeking an outstanding and motivated individual to join our team as a Principal Scientist, Cryo-EM.
Key Responsibilities:

• Be an active member of drug discovery teams, working closely with computational and medicinal chemists on structure-based drug design approaches for small/large molecule optimization.
• Be responsible for end-to-end high-resolution structure determination via Cryo-EM including sample and cryo-EM grid optimization, data collection, processing, and structure refinement, and communicating these results to the project teams.
• Collaborate closely with protein scientists, biophysicists, protein NMR, and X-ray crystallography scientists as part of an integrated structural biology effort.
• Actively seek innovative strategies to handle complex targets including grid preparation, data collection, processing, and analysis.
• Contribute to increasing the structural biology scientific expertise of the group by publishing high-impact research papers, attending and presenting at scientific conferences, internalizing impactful outside technologies and techniques, and establishing academic collaborations.
• Mentor lab scientists and contribute to the strategic planning of the Structural Biology group.

Qualifications

Education:

• Ph.D. or equivalent and postdoctoral experience in structural biology (Cryo-EM, X-ray crystallography, biophysics, protein engineering) or related field is required

Experience and Skills:

Required:

• Minimum 3 years of industry experience is required
• Deep scientific expertise in structural biology, with strong experience in sample preparation using Vitrobot, data collection via EPU, and structure determination are required
• Strong record of external publications and presentations is required
• Outstanding written and oral communication skills are required

Preferred:

• Experience in cryo-ET/FIB milling, and Micro-ED is preferred
• Experience in machine learning and docking programs (e.g., Schrdinger) is preferred
• Experience in structure-guided small/large molecule design utilizing Cryo-EM/X-ray is preferred
• Knowledge of protein production techniques and protein stability requirements is preferred
• Broad knowledge of biophysics (such as ITC, DSF, SPR, ASMS, HDX-MS), biochemistry, molecular pharmacology, and protein sciences is preferred
• Expertise in one or more of the following therapeutic areas: Oncology, Inflammation, Neuroscience, Cardiovascular, and Infectious Diseases is preferred

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

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