WHY JOIN US?At Alexion, a division of AstraZeneca, we are driven by a shared purpose to transform the lives of people affected by rare and devastating diseases. By combining deep expertise in rare disease with the scale, science, and innovation of AstraZeneca, we are working to deliver meaningful advances for patients and families with significant unmet needs.
Join us at an exciting time as we continue to evolve how technology, data, digital capabilities, and AI support our Commercial organization. You will have the opportunity to work closely with business and technology leaders, shape solutions that enable new product launches and commercial transformation, and help turn emerging technologies into measurable outcomes for patients and the business.
Our culture is built on collaboration, innovation, and continuous learning. We encourage our people to challenge convention, explore new possibilities, and bring forward ideas that can improve how we work and how we serve patients. As part of Alexion, you will have the opportunity to make an impact in a highly specialized area of healthcare while benefiting from the capabilities and global reach of AstraZeneca.
Hybrid PolicyWe also recognize the importance of flexibility and balance. Our ways of working support both individual needs and meaningful in-person collaboration. This role is based in Boston, MA, with
employees expected to work from the office three days per week, creating opportunities for teams to connect, collaborate, and solve complex challenges together.
IntroductionAs Director, RDU IT Business Partner, US Commercial, you will serve as a senior business-facing technology partner, shaping and delivering technology, data, digital, and AI-enabled capabilities that support commercial priorities, launch readiness, commercial transformation, and improved patient outcomes.
This position is based in Boston, MA, and may require up to 20% travel.About the RoleThe Director, RDU IT Business Partner, US Commercial will serve as a senior IT Business Partner for the US Commercial organization, with a defined portfolio spanning Commercial business functions, Commercial Training, Rare Disease Therapy Area teams, launch, Finance, Commercial Operations, Market Access, and enabling functions and AI-enabled transformation.
This role will build trusted relationships with senior Commercial stakeholders, shape the multi-year technology and AI roadmap for assigned business areas, lead demand prioritization, steward portfolio health, and partner across IT, Digital, Data, AI, Architecture, Cybersecurity, Privacy, Compliance, Finance, Service Delivery, and external partners to deliver measurable business outcomes.
Key Responsibilities- Serve as a senior IT Business Partner and trusted advisor for assigned US Commercial business areas, aligning technology, data, digital, and AI roadmaps to business priorities.
- Build and maintain trusted relationships with senior stakeholders across US Commercial, Commercial Training, Rare Disease Therapy Area teams, launch, Finance, Commercial Operations, Market Access, and enabling functions.
- Partner with business leaders to translate strategic objectives into capability roadmaps, prioritized demand, investment options, and measurable outcomes.
- Steward assigned Commercial IT portfolio activities, including demand intake, prioritization, funding alignment, risks, dependencies, value realization, ServiceNow visibility, and executive reporting.
- Lead disciplined business capability mapping and technology roadmap development, ensuring roadmaps reflect business strategy, process maturity, data readiness, AI opportunity, and adoption needs.
- Support Market Access and GTN priorities at the portfolio level by translating key business needs into scalable, compliant technology and data-enabled solutions.
- Ensure assigned commercial solutions include appropriate governance, compliance, privacy, financial controls, adoption planning, and measurable value outcomes.
- Lead launch technology planning for new products, indications, and therapy area priorities with Sales, Marketing, Commercial Training, Market Access, and business operations.
- Lead through influence across business, IT, data, AI, architecture, delivery, and vendor teams; coach colleagues on business partnering, AI literacy, portfolio governance, executive communication, and value realization.
AI-Ready Business Partner Responsibilities- Enable AI for the business by identifying, framing, prioritizing, and scaling high-value AI, GenAI, agentic AI, automation, analytics, and data product opportunities across US Commercial workflows.
- Translate AI ideas into business-ready use cases with clear problem statements, target users, data requirements, operating model impacts, success measures, risks, and adoption requirements.
- Drive AI-enabled business outcomes across commercial decision support, launch readiness, Commercial Training enablement, executive reporting, forecasting support, customer engagement, and portfolio prioritization.
- Champion responsible AI adoption by partnering with Data, AI, Architecture, Cybersecurity, Privacy, Legal, Compliance, and business stakeholders to define explainability, traceability, human oversight, auditability, security, and value measurement requirements.
- Move the business from AI experimentation to measurable business impact by defining baselines, success metrics, adoption targets, governance requirements, and continuous improvement loops.
- Model AI-enabled business partnering by using approved AI tools and LLM-enabled workflows to improve stakeholder preparation, meeting synthesis, portfolio reporting, roadmap development, risk identification, executive communication, and follow-through.
- Use AI-assisted analysis to improve demand intake, synthesize stakeholder feedback, compare requirements, identify duplicate or overlapping requests, and generate clearer business problem statements.
- Apply AI to organize knowledge, transition documentation, initiative history, open risks, dependencies, decisions, and stakeholder context while validating outputs and protecting sensitive information.
- Coach business and IT partners with practical, compliant AI usage patterns that improve productivity, quality, decision speed, and accountability.
Essential Qualifications- Bachelor's degree in computer science, MIS, Business, Life Sciences, Data / Analytics, or related fields.
- 12+ years of experience in IT, digital, data, commercial technology, or enterprise technology roles, including business partnership, portfolio ownership, solution delivery, and cross-functional leadership.
- Experience working in biotech, pharmaceutical, medical device, life sciences, or another regulated industry.
- Demonstrated experience as a senior IT Business Partner or technology leader supporting Commercial, Sales, Marketing, Market Access, Patient Services, Commercial Operations, Finance, or related business functions.
- Strong understanding of US Commercial business processes, launch planning, sales and marketing operations, commercial operations, portfolio governance, and value realization.
- Working knowledge of Market Access, GTN, commercial operations, and related financial decision-support processes.
- Experience shaping or delivering data, analytics, digital, automation, AI, or technology-enabled transformation capabilities.
- Experience with CRM and related commercial platforms such as Salesforce, Veeva, or other life sciences commercial technologies.
- Strong understanding of data products, analytics, reporting, commercial data foundations, SDLC, Agile practices, privacy, security, quality, compliance, and regulatory expectations.
- Experience managing portfolio funding, business cases, risks, dependencies, vendor engagement, and executive-level reporting.
- Ability to influence senior stakeholders, simplify complexity, drive alignment, communicate technology concepts in business language, and connect technology investments to business value, patient impact, efficiency, adoption, and risk reduction.
Preferred Qualifications- Master's degree preferred.
- Experience supporting Commercial, Finance, Patient Services, Launch Excellence, Commercial Training, Market Access, or Rare Disease Therapy Area technology portfolios.
- Experience with Salesforce Health Cloud, Salesforce Life Sciences Cloud, Veeva, Service Cloud, Experience Cloud, ServiceNow, Snowflake, data products, BI / analytics platforms, or AI-enabled commercial platforms.
- Experience with rare disease commercial models, specialty pharmacy, patient access, payer engagement, field reimbursement, care coordination, or high-touch business-facing environments.
- Experience leading governance forums, executive portfolio reviews, vendor partnerships, product-oriented operating models, transformation programs, adoption plans, and value-realization plans.
- Familiarity with responsible AI principles, including explainability, traceability, human oversight, auditability, privacy, compliance, risk management, and adoption of governance.
- Strong leadership presence with the ability to balance strategic thinking, operational discipline, stakeholder empathy, and execution focus.
SO, WHAT'S NEXT?To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience - it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.
Where can I find out more?- Explore what we're building: ;/li>
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Apply today to shape the future of AI-powered rare disease care! Alexion is an equal opportunity employer that is committed to diversity and inclusion and providing a workplace that is free from discrimination. Alexion is committed to accommodating persons with disabilities. Such accommodation is available on request in respect of all aspects of the recruitment, assessment and selection process and may be requested by emailing
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The annual base pay for this position ranges from $153,018.40 - $200,836.65 USD. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience.
In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program. Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans.
Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.
Date Posted25-Sept-2026
Closing Date08-Oct-2026
Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.
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