Sr. Systems Engineer

Job Position: Sr. Systems Engineer
Job Location: Pleasanton, CA (Onsite)

Job Description and Position Summary:

• We are seeking a highly motivated Senior System Engineer to join our End-to-End Solution Integration Chapter supporting Next-Generation Diagnostic Solutions.
• In this hands-on role, you will drive feasibility, development, and integration of complex multi-disciplinary systems spanning sample preparation, library preparation, molecular detection technologies (e.g., digital PCR, sequencing by synthesis, microarray), and bioinformatics/data processing pipelines.
• You will collaborate with assay, software, hardware, and bioinformatics teams to define, integrate, and optimize system-level performance, ensuring technical robustness and operational scalability across diverse technologies.
• This role is ideal for a systems-minded engineer with direct industry experience in sequencing workflows, strong analytical and statistical skills, and the ability to influence cross-functional projects without formal people management responsibilities.

Key Responsibilities:

• Systems Development, Integration & Analysis
• Drive system-level development activities across wet lab workflows, instruments, and data pipelines for next generation diagnostic solutions.
• Perform hands-on system integration and troubleshooting of workflows including sample extraction, library preparation, molecular detections, and data transfer.
• Partner with assay, software and bioinformatics teams to ensure seamless integration of sequencing output with downstream analysis pipelines.
• Contribute to system architecture, requirements definition.
• Apply statistical analysis and Design of Experiments (DoE) methodologies (e.g., JMP, ANOVA, regression) to characterize, optimize, and set subsystem specifications.

Verification, Validation & On Market support:

• Plan, design and execute verification and validation (V&V) test cases to ensure comprehensive coverage of requirements.
• Analyze test results for accuracy, validity, and relevance to user needs.
• Support post-launch troubleshooting and field investigations through failure mode and root cause analyses.

Collaboration & Influence:

• Represent Systems Engineering in cross-functional project teams on key topics such as requirements management, defect management, system integration, etc.
• Collaborate closely with assay scientists, software developers, hardware engineers, and bioinformaticians to align on end-to-end workflows.
• Contribute to system documentation, including requirements, specifications, integration plans, and verification results.
• Identify and lead opportunities for workflow simplification, automation, and continuous improvement.

Qualifications:

• We are hiring a Senior System Engineer with major in Systems Engineering, Bioengineering, Biomedical Engineering.
• The final compensation will be determined by the candidate's experience and qualifications.

Senior Engineer Level:

• PhD degree with related field with 5+ years of relevant industry experience is highly valued.
• Master’s degree with 10+ years of relevant industry experience; Or Bachelor’s degree with 10+ years of relevant industry experience. Experience:
• hands-on industrial experience with sequencing related workflows, including nucleic acid extraction, library preparation, and sequencing.
• Proven lab troubleshooting experience in sequencing workflows and PCR-based workflows.
• Exposure to bioinformatics/data processing pipelines for sequencing output (variant calling, data QC) is highly desirable.
• Experience with statistical tools and DoE methodologies (JMP, regression, ANOVA) is required.
• Familiarity with system-level product development in life sciences instrumentation is a plus.
• Experience across multiple product life-cycle stages is a plus.
• Experience in digital PCR platforms is desirable.
• Experience with developing In-vitro Diagnostic products is desirable.
• Experience in implementing workflow on semiconductor based sensing devices or microfluidic devices is desirable.

Skills:

• Strong analytical and problem-solving skills with the ability to work independently.
• Excellent written and verbal communication skills to influence cross-functional stakeholders.
• Scripting/programming experience (Python, R, or equivalent) is a plus.

Who You Are:

• You are a fast learner who thrives at the interface of biology, technology, and data. You want to translate complex scientific workflows into reliable, scalable system solutions.
• You are collaborative, curious, and driven to make an impact across diverse disciplines, and is comfortable operating as an individual contributor with broad cross-functional influence.

Interview:

1 phone screening

2. Onsite