Scientist I

Description:

Job Title: Scientist I
Working Model: Fully Onsite - 9360 Towne Centre Dr, San Diego, CA 92121
Working Days: Monday through Friday
Working Hours: 9 AM to 5:30 PM PT
Roche Bill Rate: ***/hr Max
Interview Model: Two rounds (Virtual - 30 minutes each)

Job description

We seek an outstanding candidate to join the gRED Gene Therapy Nanotechnology team. The Scientist I will contribute to our cutting-edge delivery platform by designing, preparing, and characterizing ligand conjugates and targeted lipid nanoparticles. A critical component of this role is supporting targeted delivery systems through bioconjugation chemistry, including preparing protein conjugates and formulating targeted LNPs. Responsibilities include executing bioconjugations (e.g., antibodies, peptides) with small molecules or polymers; validating and purifying bioconjugates via LC-TOF and ÄKTA purification station; formulating non-targeted and targeted LNPs encapsulating nucleic acids using microfluidic or T-junction mixing technologies; performing surface bioconjugation for targeted LNPs; supporting analytical assay development (BLI, fluorescence microscopy, ÄKTA); evaluating ligand and particle stability under various conditions; maintaining electronic laboratory notebooks; and authoring SOPs.

Skills

Extensive hands-on experience in bioconjugation methodologies, process optimization, and bimolecular reaction kinetics. Prior expertise in Antibody-Drug Conjugate (Client) development is strongly preferred.

Proven experience with lipid nanoparticle formulation and LNP characterizations via RiboGreen, Dynamic Light Scattering (DLS), and Zeta potential measurement.

Proficiency in bioconjugation and formulating buffers is required.

Excellent attention to detail and ability to produce consistent results and effectively communicate with cross-functional teams.

Proficiency in MS Excel is required; prior experience with advanced analytical software (Prism, JMP) is desirable.

Excellent oral and written communication skills.

Education

MS with 2+ years or BS with 5+ years in pharmaceutical sciences, bioengineering, chemical engineering, chemistry, or a related scientific discipline (an equivalent combination of education and experience may be considered).