Principal Applications Developer

The Regeneron Genetics Center IT group seeks a Principal Applications Developer to work on critical systems supporting groundbreaking genetic research. In this role, you'll serve as a subject matter expert, building and delivering end-to-end solutions for high-performance application interfaces and enterprise-scale data pipelines around our extensive genetic datasets. You'll work on complex distributed systems, contribute to technical strategy, and develop solutions that enable researchers to query vast amounts of data with speed and precision.

As a Principal Applications Developer, a typical day might include:

• Building and delivering enterprise-scale ETL solutions using TypeScript, Python, and AWS cloud services, developing sophisticated data pipelines that manage massive genetic datasets with efficiency and reliability
• Working on distributed systems end-to-end taking responsibility for development, maintenance, performance optimization, and operational excellence of complex systems
• Developing APIs and integration solutions for expanding services, building reliable APIs that enable efficient information access and integration
• Optimizing database performance through advanced SQL tuning, indexing strategies, partitioning schemes, caching mechanisms, and comprehensive performance monitoring to achieve optimal query response times
• Leveraging AI-powered development tools to accelerate coding, testing, and deployment workflows, enhancing overall team productivity
• Collaborating as a technical partner with research teams to understand complex requirements, translate them into technical solutions, and deliver systems that perform at scale

This job might be for you if, you have:

• Enterprise ETL expertise: Demonstrated hands-on experience building and implementing enterprise-scale ETL processes for complex data environments
• Cross-domain capability: Proven expertise working across both data pipeline engineering and API/service development to deliver complete solutions end-to-end
• Advanced technical depth: Expert-level capabilities in database optimization, distributed systems development, and cloud-native application development
• Adaptability: Thrives in a dynamic research environment with rapidly evolving priorities and emerging technical challenges
• Quality-driven mindset: Meticulous attention to detail with unwavering commitment to testing, benchmarking, and validation at scale

To be considered for this role, you must have a Bachelor's Degree or higher with at least 6 years of relevant IT experience building cloud native applications and hands on experience with the following: Python, TypeScript, Docker, ETL orchestration, PostgresSQL or MySQL, Redshift or SnowFlake, Cloud Services (AWS preferred).

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive culture that provides comprehensive benefits, which vary by location. In the U.S., benefits may include health and wellness programs (including medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave) for eligible employees at all levels! For additional information about Regeneron benefits in the US, please visit For other countries' specific benefits, please speak to your recruiter.
Please be advised that at Regeneron, we believe we are most successful and work best when we are together. For that reason, many of Regeneron's roles are required to be performed on-site. Please speak with your recruiter and hiring manager for more information about Regeneron's on-site policy and expectations for your role and your location.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

Salary Range (annually)

$128,600.00 - $210,000.00