Software Guidance & Assistance, Inc., (SGA), is searching for a Scientist II for a Contract assignment with one of our premier Pharmaceutical clients in South San Francisco, CA .
Responsibilities :
- Execute and optimize research-scale lentiviral vector production workflows, including approaches that support increased production capacity and transition to suspension culture.
- Produce and characterize research-grade lentiviral vectors for in vitro evaluation and, as needed, to support preclinical in vivo studies.
- Develop, optimize, and execute molecular and cell-based assays to assess vector quality, titer, gene delivery, CAR expression, and functional activity.
- Perform primary human cell culture and engineering studies to support evaluation of delivery platforms for in vivo cell therapy applications.
- Apply flow cytometry to assess transduction efficiency, CAR expression, and cell phenotype.
- Collaborate with project teams to define material requirements, coordinate production timelines, and provide supporting analytical data.
- Independently plan experiments, troubleshoot technical challenges, and interpret results in collaboration with project team members.
- Analyze and communicate findings through clear experimental summaries and presentations at internal scientific meetings.
- Maintain accurate and timely electronic laboratory records, document methods, and contribute to reproducible workflows.
- Support laboratory operations, including equipment onboarding and maintenance, and adhere to applicable biosafety, laboratory safety, and training requirements.
Required Skills :
- A self-motivated candidate with a (BS/ MS) + 5 years industry experience, or PhD in Immunology, Virology, Molecular Biology, Bioengineering, Cell Biology, or a related discipline.
- Hands-on experience with lentiviral vector production and characterization.
- Strong proficiency in aseptic mammalian cell culture and experience working with primary human immune cells, preferably T cells.
- Experience developing, optimizing, and troubleshooting molecular or cell-based analytical assays.
- Technical proficiency in flow cytometry and at least one quantitative molecular assay platform, such as qPCR or ddPCR.
- Demonstrated ability to independently design experiments, critically interpret data, and resolve technical challenges.
- Strong organizational, documentation, and communication skills, with the ability to manage concurrent experiments and collaborate effectively.
Preferred Skills :
- Three or more years of relevant post-graduate research experience in biotechnology, pharmaceutical research, or an academic setting.
- Experience producing or characterizing gene delivery vectors for in vivo CAR T or related preclinical research programs.
- Experience with suspension-based lentiviral vector production, scale-up, or process development.
- Experience with CAR T-cell functional assays and multiparameter flow cytometry.
- Experience with nonviral delivery platforms, genome engineering, or next-generation sequencing.
- Familiarity with automation, liquid handling, and high-throughput analytical workflows.
- Proficiency with relevant analysis and documentation tools, such as FlowJo, GraphPad Prism, and Benchling.
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SGA is a technology and resource solutions provider driven to stand out. We are a women-owned business. Our mission: to solve big IT problems with a more personal, boutique approach. Each year, we match consultants like you to more than 1,000 engagements. When we say let's work better together, we mean it. You'll join a diverse team built on these core values: customer service, employee development, and quality and integrity in everything we do. Be yourself, love what you do and find your passion at work. Please find us at .
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SGA is an Equal Opportunity Employer and does not discriminate on the basis of Race, Color, Sex, Sexual Orientation, Gender Identity, Religion, National Origin, Disability, Veteran Status, Age, Marital Status, Pregnancy, Genetic Information, or Other Legally Protected Status. We are committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, and our services, programs, and activities. Please visit our company to request an accommodation or assistance regarding our policy.
