Aptask Global Workforce (AGW) is seeking a Scientist, Complex in Vitro Systems (Lung Focus) - Onsite for a contract position with a Global Biotechnology Company located in South San Francisco, CA. This is a 12-month contract opportunity. The Complex in Vitro Systems (CiS) Lab within the Department of Translational Safety is seeking a highly motivated Scientist to develop, characterize, and qualify advanced complex in vitro models to support our client's mission of delivering safe and efficacious medicines. In this lab-based role, you will provide scientific and technical expertise to support the development and implementation of human lung complex in vitro models (CIVM), including lung organoids, air-liquid interface (ALI) cultures, and lung microphysiological systems for drug development. The successful candidate will excel in a dynamic, collaborative research environment, demonstrate exceptional problem-solving skills, and effectively communicate across scientific disciplines.
Responsibilities: - Development, qualification, and implementation of innovative in vitro lung model systems (e.g., airway and alveolar organoids, ALI cultures, lung-on-a-chip co-culture platforms) to support disease modeling and lung safety risk assessment
- Designing and executing experiments to characterize lung models, including evaluation of cell viability, morphology, and barrier integrity and function, using techniques such as cytotoxicity assays, confocal and high-content imaging, transepithelial resistance/permeability assays, and transcriptomic and proteomic analyses
- Collaborating closely with cross-functional teams to align on complex model building with therapeutic strategies and program needs
- Analyzing, interpreting, and clearly communicating study results to collaborators and stakeholders, and contributing to internal and external scientific presentations as appropriate
- Maintaining comprehensive electronic documentation in accordance with departmental Standard Operating Procedures (SOPs) and contributing to study reports, safety assessments, and final deliverables
Requirements: - PhD in Bioengineering, Cell Biology, Molecular Biology, Toxicology (or related fields) with 0-5 years of experience post-PhD with hypothesis-driven research in industry or academia
- Experience in culturing multiple lung cell types, including relevant lung primary cells and cell lines
- Proven expertise in developing, qualifying, and applying airway or alveolar organoids, co-culture systems, and microphysiological or microfluidic platforms, to support drug discovery and translational research
- Proficiency with quantitative and qualitative characterization techniques such as qRT-PCR, RNA-seq, proteomics, immunofluorescence and confocal microscopy, live-cell and time-lapse imaging, high-content imaging/screening, and analysis of data generated from these assays
- Strong experimental design skills, with demonstrated ability in troubleshooting, method development, and protocol optimization for complex in vitro systems
- A collaborative, team-oriented scientist who prioritizes shared objectives and communicates effectively across disciplines, with a strong work ethic grounded in scientific rigor, attention to detail, and a commitment to excellence
Desired skills: - Experience in lung biology and immunology is a strong plus
- Advanced proficiency in MATLAB and/or Python for image processing, algorithm development, and large-scale data analysis
Pay range: up to $58.91 per hour
Only candidates available and ready to work directly as Aptask Global Workforce (AGW) employees will be considered for this position. If you have the described qualifications and are interested in this exciting opportunity, apply today! Aptask Global Workforce (AGW) ApTask Global Workforce (AGW) is a certified Minority and Veteran workforce solutions company. AGW delivers operational, clinical, lab and professional talent with a strong focus on healthcare and life sciences. The company supports clients with reliable staffing, program expertise and a commitment to quality, speed and consistent delivery.
Benefits of working with ApTask Global Workforce include: - Medical
- Dental
- Vision
- Sick Pay (for applicable states/municipalities)
Our team stays close to the process and is here to guide you every step of the way. To learn more, please visit our website
ApTask Global Workforce is an Equal Opportunity Employer. Candidates will receive consideration without regard to their race, color, religion, sex, sexual orientation, gender identity, national origin, disability or status as a protected veteran.
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