AI/ML Research Scientist
Trail Blazer Consulting LLC
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Job Details
Skills
- Computational Biologist
- Computational Biology
- Computational Scientist
- Machine Learning Scientist
- Research Scientist
- Bioinformatics Scientist
- RNA
- Oligonucleotide
- ASO
- Antisense
- siRNA
- Protein Design
- Peptide Design
- Antibody Design
- Machine Learning
- Deep Learning
- Generative AI
- PyTorch
- TensorFlow
Summary
Must Haves:
• PhD in Computational Biology, Computational Chemistry, Machine Learning, Bioengineering, Chemical Engineering, or a related field, with 1–2 years of relevant industry or postdoctoral experience
• Must have knowledge in: One of the following: RNA, Oligonucleotide, Peptide, or Antibody design.
• Hands-on experience building deep learning, generative, or agentic AI models for nucleic acid and/or protein design
• Proficiency in Python and modern ML frameworks (e.g., PyTorch, JAX, TensorFlow, scikit-learn), with working knowledge of R and SQL
• Strong working knowledge of oligonucleotide design principles, such as hybridization thermodynamics, target accessibility, and RNA secondary structure
Job Description
In this role, you will develop sequence-aware predictive models that prioritize oligonucleotide therapeutics by exon-skipping response, integrating sequence, thermodynamic, and pre-mRNA structural features, and extend these approaches across PMOs, gapmers, siRNA–PMO hybrids, and conjugate designs. You will also contribute to AI/ML-driven de novo design and multi-objective optimization of antibodies, peptides, and other biologics, including modeling of protein structure and antibody–antigen interactions. Working closely with chemists, biologists, and data scientists, you will benchmark and prospectively validate model predictions, helping turn computational insights into experimentally tested designs and expanding the client's cross-modality design and decision-support capabilities.
Requirements:
• PhD in Computational Biology, Computational Chemistry, Machine Learning, Bioengineering, Chemical Engineering, or a related field, with 1–2 years of relevant industry or postdoctoral experience
• Hands-on experience building deep learning, generative, or agentic AI models for nucleic acid and/or protein design
• Proficiency in Python and modern ML frameworks (e.g., PyTorch, JAX, TensorFlow, scikit-learn), with working knowledge of R and SQL
• Strong working knowledge of oligonucleotide design principles, such as hybridization thermodynamics, target accessibility, and RNA secondary structure
• Experience modeling exon-skipping efficiency or ASO/siRNA potency from sequence and pre-mRNA structural features
• Experience with protein and RNA language models (e.g., ESM, RNA-FM), structure prediction tools (e.g., AlphaFold, RoseTTAFold), and molecular modeling platforms (e.g., Schrödinger, MOE)
• Exposure to computational modeling of antibody–antigen sequence, structure, and binding interactions
• Familiarity with uncertainty quantification or active learning to guide experimental design
• Experience with reproducible development and deployment practices, including Git (GitHub/GitLab), Docker, database systems, and cloud computing (AWS preferred)
• Strong communication and collaboration skills across multidisciplinary teams of chemists, biologists, and data scientists, with a commitment to tackling challenges and continuous learning
- Dice Id: 91093714
- Position Id: 9137215
- Posted 14 minutes ago
Company Info
About Trail Blazer Consulting LLC
At TRAIL BLAZER we help our IT consultants explore different industries, multiply their skills, and accelerate their career growth with industry-leading firms. We offer the flexibility of direct hire placements, temporary, and project work. With offices nationwide, TRAIL BLAZER combines the resources of a national network with in- depth local expertise. We offer the flexibility of direct placements, and project work.
Trail Blazer Consulting LLC is headquartered in Astoria, NY, USA. We are a leading professional consulting firm with a global database of applicants and state of art technology and process to identify the best and brightest skills.Trail Blazer is committed to provide customer satisfaction through commitment highest standards of services. With a range of skill sets and a flexible support network, we can deliver quick and cost effective resources to our valued Clients. We spend a considerable amount of time and resources screening and hiring top quality consultants, which allows us to provide premier resources that meet and exceed our client expectations.
OUR MISSION, VISION& VALUES:
We at TRAIL BLAZER CONSULTING believe in attaining success. We know that success is important to both our associates and our clients. Our mission is to understand and deliver 100%. With our commitment towards our clients, it helps us in achieving growth, innovation and excellence. We want to be an integral part of that process. To that end, we believe in the following Mission & Vision Statements and set of Core Values:
STAFF AUGMENTATION:
Staff Augmentation, or better known as subcontracting, is primarily outsourcing of manpower on a skill requirement or project completion basis for a limited period of time. From the past few years the IT departments have gone through a difficult phase as they have been pressed to deliver impressive results on multiple initiatives with limited staff. Staffing may be desired when there are a dynamic temporary or permanent people or skilled staff.
IT CONSULTING:
TRAIL BLAZER brings together the key IT consulting services that address aspects of reducing cost, increasing agility and enabling transformation. Our consultations are based on an analytical approach to understand the business problems, resulting in the practical recommendation and actionable plans. Our value proposition is based on a confluence of business knowledge, deep hands-on technology skills and a focused approach through the use of in-house methodologies, frameworks and tools.
CORE VALUES:
TRAIL BLAZER CONSULTING core values convey who we are as an organization and how we deliver value.
VOLUNTEER
our time, talent & resources
ACCOUNTABILITY
as we pursue our aspirations
LEGACY
to impact others lives
UNBEATABLE
as we collaborate & compete
EXTRAORDINARY
in all we do