Sr. Research Scientist – Biochemistry

Wilmington, DE, US • Posted 5 days ago • Updated 5 days ago
Contract W2
12 Months
No Travel Required
On-site
$35/hr
Fitment

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Job Details

Skills

  • FI
  • HTRF
  • FP
  • SPR
  • BLI
  • ITC
  • DSF
  • electronic lab notebooks
  • ELN

Summary

Job Title: Sr. Research Scientist – Biochemistry
Location: Onsite, Wilmington, DE

Position Overview

We are seeking a highly skilled Sr. Research Scientist – Biochemistry to support drug discovery efforts through the design, development, and execution of biochemical and biophysical assays. This role will play a critical part in hit identification, validation, and mechanistic studies for small molecules and other therapeutic modalities.

 

Key Responsibilities

  • Design, develop, and execute biochemical assays (e.g., FI, HTRF, FP) and biophysical assays (e.g., SPR, BLI, ITC, DSF)
  • Conduct high-throughput screening (HTS) to evaluate compound libraries and characterize binding kinetics (IC₅₀, Kd, kon, koff)
  • Troubleshoot assay performance, optimizing for robustness, reproducibility, and scalability
  • Analyze and interpret experimental data using tools such as GraphPad Prism and Genedata
  • Support protein expression and purification workflows using chromatography techniques (affinity, ion-exchange, size-exclusion)
  • Operate and maintain lab instrumentation including plate readers and automated liquid handling systems
  • Maintain accurate documentation using electronic lab notebooks (ELN) and contribute to technical reports and presentations

 

Required Qualifications

  • Bachelor’s, Master’s, or Ph.D. in Biochemistry, Chemistry, Biophysics, Chemical Biology, or related field
  • Strong foundation in enzymology and assay development
  • Hands-on experience in protein purification and biochemical/biophysical characterization
  • Proficiency with data analysis tools (GraphPad Prism, Genedata, or similar)
  • Experience working in a laboratory setting with strong attention to detail and documentation
Employers have access to artificial intelligence language tools (“AI”) that help generate and enhance job descriptions and AI may have been used to create this description. The position description has been reviewed for accuracy and Dice believes it to correctly reflect the job opportunity.
  • Dice Id: 10120317
  • Position Id: 8991766
  • Posted 5 days ago
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Chandee Pandey

Chandee Pandey

Recruiter! @ Sovereign Technologies
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