Systems Engineer II

Santa Clara, CA, US • Posted 17 hours ago • Updated 5 hours ago
Contract W2
On-site
Fitment

Dice Job Match Score™

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Job Details

Skills

  • Next Generation Sequencing
  • System Integration
  • Statistics
  • Root Cause Analysis
  • Collaboration
  • Test Cases
  • Product Requirements
  • Verification And Validation
  • Organized
  • Assays
  • Instrumentation
  • Bioinformatics
  • Continuous Improvement
  • Reliability Engineering
  • Chemistry
  • Science
  • PCR
  • DNA Sequencing
  • Extraction
  • MATLAB
  • Git
  • Data Analysis
  • Python
  • JMP
  • Regression Analysis
  • Analysis Of Variance
  • Design Of Experiments
  • Statistical Process Control
  • ROOT
  • Workflow
  • Documentation
  • Management
  • Multitasking
  • Adaptability
  • Communication
  • Relationship Building

Summary

Job Title: Systems Engineer II
Location: Santa Clara, CA 95050 (Onsite)
Duration: 12 Months with strong possibility of extension
Job Description:
The Sequencing team is seeking a passionate Systems Engineer II to join the Systems Integration Group supporting Next Generation Sequencing (NGS) products. This is a hands-on role in which the Systems Engineer II will contribute to feasibility, development, and integration activities for end-to-end NGS solutions.
As a member of the Systems Integration team, this individual will work with a Single Molecule Sequencing platform to optimize operating protocols, design and perform wet-lab experiments, support integration of system subcomponents, and help improve the overall sequencing solution.
Key Responsibilities
  • Design, execute, analyze, and document experiments to support feasibility, development, integration, verification, and validation of NGS workflows.
  • Perform sample preparation, library preparation, sequencing-related experiments, and verification studies.
  • Use the Single Molecule Sequencing platform to optimize final operating protocols and support system-level integration activities.
  • Interpret experimental results using appropriate experimental design and statistical analysis methods.
  • Troubleshoot instrument, workflow, or assay-related failures using standard root cause analysis methods.
  • Collaborate with subject matter experts to understand failure modes and identify appropriate solutions.
  • Develop, execute, and document test cases based on product requirements for verification and validation activities.
  • Maintain accurate, well-organized, and concise laboratory records using best laboratory practices.
  • Work cross-functionally with assay, instrumentation, software, bioinformatics, and systems teams to resolve integration challenges.
  • Support continuous improvement of sequencing performance, including coverage, throughput, robustness, reproducibility, and overall system reliability.
Required Qualifications
  • Bachelor's degree in chemistry, science, engineering, or a related field with 5 years of relevant experience, or a Master's degree in a related field with 1-3+ years of relevant experience.
  • Demonstrated hands-on experience with PCR, DNA sequencing methods, raw sample preparation, nucleic acid extraction, library preparation, and/or NGS sequencing.
  • At least 2 years of experience using MATLAB, Git, Python, or similar tools for data analysis and/or automation.
  • Experience with statistical tools and methods, such as Python, JMP, regression analysis, and ANOVA.
  • At least 2 years of experience with Design of Experiments methodology and application of statistical process control.
  • Demonstrated ability to troubleshoot technical issues and identify root causes in laboratory, instrument, or workflow settings.
  • Strong documentation skills and commitment to following best laboratory practices.
Preferred Qualifications
  • Proven track record of performing in a fast-paced, matrixed environment.
  • Ability to work independently while collaborating effectively across functions.
  • Demonstrated ability to influence technical decisions and stakeholders without direct authority.
  • Experience solving unique, ambiguous, or unpredictable problems that may impact project or organizational goals.
  • Strong planning, prioritization, multitasking, and follow-through skills.
  • Highly energetic, focused, and adaptable working style.
  • Strong interpersonal, verbal communication, and relationship-building skills.
  • Demonstrated ability to build and maintain effective relationships with key stakeholders.
Employers have access to artificial intelligence language tools (“AI”) that help generate and enhance job descriptions and AI may have been used to create this description. The position description has been reviewed for accuracy and Dice believes it to correctly reflect the job opportunity.
  • Dice Id: 10105282
  • Position Id: 882888
  • Posted 17 hours ago
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