Job DescriptionThis position is a 100% remote within the United States, however, incumbent may be asked to come onsite once a month.At Mayo Clinic, we are transforming healthcare through bold innovation and we are seeking a Senior Enterprise IT Architect - AI to help lead that transformation. As a strategic leader within the Office of the CTO, you will shape and advance our enterprise AI architecture, enabling cutting-edge capabilities that directly improve patient care, research, and operational excellence. This role operates at the intersection of technology vision and real-world impact, designing scalable, secure, and ethical AI platforms that support clinical decision support, predictive analytics, generative AI, automation, and emerging intelligent systems across a world-class healthcare enterprise.
The ideal candidate is a forward-thinking architect who combines deep enterprise architecture expertise with hands-on knowledge of AI/ML ecosystems, cloud-native platforms, data strategy, governance, and responsible AI practices. You will partner with executive leadership, clinical innovators, data scientists, engineers, and security teams to define reference architectures, standards, and roadmaps that accelerate AI adoption while ensuring compliance, reliability, and trust. This is a high-visibility opportunity to influence enterprise-wide strategy and deliver meaningful, mission-driven innovation at one of the most respected healthcare organizations in the world.
Takes overall responsibility for developing a key area with strategic impact or scope of Enterprise Architecture framework or practice. Provides guidance to Enterprise and IT Architects and others as appropriate and serves as principal advisor to the Chief Architect and IT Executive Leadership on this key area. Monitors and incorporates into the practice, as appropriate, industry trends and opportunities in Enterprise Architecture. May also be responsible for technical architecture and recommendations in one or more information technology domains. Works to ensure that appropriate processes and communications are developed or modified to maintain the key framework or practice, and that the technology objectives and solutions of the enterprise are aligned to the business mission, strategy, goals, and processes. Establishes and communicates a technology vision within an Information Technology discipline. Builds a critical mass of support at all levels of the organization and across departments for a given technical direction through talks, articles, blogging, demonstrations, or interpersonal communication. Participates in major technical decisions, develops technical proposals that consider alternatives and business case, gains needed institution approvals, and works effectively across departmental organizations gaining consensus of stakeholders. Possesses and maintains a strong working knowledge of multi-platform technical environments. Serves as a leader, consultant, mentor, or tutor in many specific technical architecture areas of expertise to staff throughout the Department of Information Technology (IT). Assigns tasks to staff taking into consideration workload balancing, skill sets, technical knowledge, and criticality of the tasks. Serves on appropriate committees and acts as a resource to institutional committees on an ad hoc basis. Provides consultation in their area of expertise and facilitates institutional work groups. Leads committees to establish technical standards, promote integration of data, and/or coordination of projects across work units. Provides key input to short and long-term department strategy and budget planning. Must be customer focused and possess excellent communications and interpersonal skills to interact with a variety of personnel at various levels within and outside the institution.
During the selection process you may participate in an OnDemand (pre-recorded) interview that you can complete at your convenience. During the OnDemand interview, a question will appear on your screen, and you will have time to consider each question before responding. You will have the opportunity to re-record your answer to each question - Mayo Clinic will only see the final recording. The complete interview will be reviewed by a Mayo Clinic staff member and you will be notified of next steps.
QualificationsBachelor's degree and 10 years of experience including 8 years of demonstrated technical experience, 3 years of demonstrated leadership experience and a minimum of one year as a practicing Enterprise Architect or equivalent role; Or, Associates degree and 12 years of experience including 8 years of demonstrated technical experience, 3 years of demonstrated leadership experience and a minimum of one year as a practicing Enterprise Architect or equivalent role.
Advanced expertise in one or more of the following: TOGAF ADM cycle, Business modeling, data design, information systems design, systems integration, and service design. Advanced oral and written communication, organization, problem solving, facilitation, and meeting management skills. Advanced expertise in multiple technologies. Advanced project and deliverable consistency through repeatable and reliable performance. Advanced initiative and self-motivation to complete tasks and assignments on time. Experience working in healthcare technology. Must be able to work independently and be able to lead and mentor in a team environment. Masters degree in applicable field preferred.
Additional Preferred Qualifications:Demonstrated ability to architect and lead AI-enabled solutions across hybrid environments, including multi-cloud and on-premises platforms, with deep understanding of AI/ML ecosystems, model lifecycle management (MLOps), and emerging generative AI technologies. Functional expertise in cloud-native AI services, distributed computing, data engineering pipelines, and GPU-accelerated architectures, applying sound engineering principles to design scalable, secure, and ethical enterprise AI platforms supporting clinical, research, and operational use cases. Proven ability to develop and present enterprise requirements, reference architectures, concepts of operations, and executive-level briefings, while anticipating and resolving complex technical challenges across AI platforms, data pipelines, infrastructure, and integrations. Strong executive communication skills with experience influencing senior leadership. Certification in cloud engineering or cloud architecture is required; AI/ML specialty certifications preferred.
This vacancy is not eligible for sponsorship/ we will not sponsor or transfer visas for this position. Also, Mayo Clinic DOES NOT participate in the F-1 STEM OPT extension program.About UsWhy Mayo ClinicMayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans - to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.
Benefits Highlights - Medical: Multiple plan options.
- Dental: Delta Dental or reimbursement account for flexible coverage.
- Vision: Affordable plan with national network.
- Pre-Tax Savings: HSA and FSAs for eligible expenses.
- Retirement: Competitive retirement package to secure your future.
About the TeamJust as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is.
Equal Opportunity All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law". Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.
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