High Performance Computing jobs in San Francisco, CA

High-Performance Computing (HPC) Systems Administrator

Remote or Massachusetts

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Today

Site: The General Hospital Corporation Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part

Full-time

USD 63,648.00 - 90,750.40 per year

Senior LLM Research Scientist - Engineer

Hybrid in San Francisco, California

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3d ago

Location Note: While this role is being advertised in San Francisco to reach the West Coasts top technical talent, the position is permanently based in New York City. We are looking for researchers and engineers ready to apply world-class computational methods to drug discovery and biomolecular simulation in the heart of Manhattans growing biotech ecosystem. PrefaceThe convergence of Computational Biophysics and Foundational Machine Learning represents the current frontier of therapeutic discove

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Full-time

300000 - 800000

Machine Learning - Engineer & Researcher

Hybrid in San Francisco, California

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3d ago

Location Note: While this role is being advertised in San Francisco to reach the West Coasts top technical talent, the position is permanently based in New York City. We are looking for researchers and engineers ready to apply world-class computational methods to drug discovery and biomolecular simulation in the heart of Manhattans growing biotech ecosystem. PrefaceThis search targets the intersection of Computational Biophysics and Foundational Machine Learning, necessitating a candidate who po

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Full-time

300000 - 800000

Ph.D. - Data Scientist

Hybrid in San Francisco, California

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3d ago

Location Note: While this role is being advertised in San Francisco to reach the West Coasts top technical talent, the position is permanently based in New York City. We are looking for researchers and engineers ready to apply world-class computational methods to drug discovery and biomolecular simulation in the heart of Manhattans growing biotech ecosystem. PrefaceThis mandate targets the critical nexus of Medicinal Chemistry and Computational Biology, requiring a practitioner capable of transl

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Full-time

200000 - 240000

Software Developer - Drug Discovery

Hybrid in San Francisco, California

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3d ago

Location Note: While this role is being advertised in San Francisco to reach the West Coasts top technical talent, the position is permanently based in New York City. We are looking for researchers and engineers ready to apply world-class computational methods to drug discovery and biomolecular simulation in the heart of Manhattans growing biotech ecosystem. PrefaceThis role demands a profound convergence of Computational Biophysics and High-Performance Systems Engineering. We are seeking indivi

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Full-time

230000 - 600000

Senior Software Developer | Agentic AI

Hybrid in San Francisco, California

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3d ago

Location Note: While this role is being advertised in San Francisco to reach the West Coasts top technical talent, the position is permanently based in New York City. We are looking for researchers and engineers ready to apply world-class computational methods to drug discovery and biomolecular simulation in the heart of Manhattans growing biotech ecosystem. PrefaceThe architectural integrity of global investment and technology research relies on the seamless convergence of Agentic AI Engineerin

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Full-time

250000 - 600000

AI Native Account Executive

San Francisco, California

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4d ago

CoreWeave is The Essential Cloud for AI . Built for pioneers by pioneers, CoreWeave delivers a platform of technology, tools, and teams that enables innovators to build and scale AI with confidence. Trusted by leading AI labs, startups, and global enterprises, CoreWeave combines superior infrastructure performance with deep technical expertise to accelerate breakthroughs and turn compute into capability. Founded in 2017, CoreWeave became a publicly traded company (Nasdaq: CRWV) in March 2025. Le

Full-time

USD 165,000.00 - 200,000.00 per year

AI System Research and Development Engineer - Optimization

Menlo Park, California

•

Today

At Snowflake, we are powering the era of the agentic enterprise. To usher in this new era, we seek AI-native thinkers across every function who are energized by the opportunity to reinvent how they work. You don't just use tools; you possess an innate curiosity, treating AI as a high-trust collaborator that is core to how you solve problems and accelerate your impact. We look for low-ego individuals who thrive in dynamic and fast-moving environments and move with an experimental mindset - who ra

Full-time

USD 200,000.00 - 287,500.00 per year

Staff Software Engineer, Databases

Remote or Palo Alto, California

•

Today

PsiQuantum's mission is to build the first useful quantum computers-machines capable of delivering the breakthroughs the field has long promised. Since our founding in 2016, our singular focus has been to build and deploy million-qubit, fault-tolerant quantum systems. Quantum computers harness the laws of quantum mechanics to solve problems that even the most advanced supercomputers or AI systems will never reach. Their impact will span energy, pharmaceuticals, finance, agriculture, transportati

Full-time

USD 180,000.00 - 205,000.00 per year

Technical Lead

San Francisco, California

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10d ago

As the Technical Lead for Client Devices, you will own the lifecycle, security, and performance of all endpoint hardware and software within the lab environment. This includes high-performance workstations, mobile devices, and specialized lab-connected peripherals. Your mission is to ensure researchers have seamless, secure access to critical tools while maintaining strict compliance and data integrity. You will lead the strategic design, implementation, and management of the client device infra

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Full-time, Third Party

Depends on Experience

Senior Lead Software Engineer- AI Platform engineer

San Francisco, California

•

Today

Job Description Be an integral part of an agile team that's constantly pushing the envelope to enhance, build, and deliver top-notch technology products. As a Senior Lead Software Engineer at JPMorgan Chase within the Corporate Sector, Infrastructure Platforms team, you are an integral part of an agile team that works to enhance, build, and deliver trusted market-leading technology products in a secure, stable, and scalable way. Drive significant business impact through your capabilities and c

Full-time

USD 171,000.00 - 260,000.00 per year

Research Computing Cloud Engineer

Remote or Stanford, California

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Today

*This is a 3-year fixed term position. Position Overview We are seeking a highly skilled Cloud Engineer to help build the next generation of Stanford's research computing environment. This role will work on multiple projects and you will design and implement scalable, secure cloud architectures that may include high-performance computing (HPC) and cutting-edge AI/ML workloads. Key Responsibilities Research, HPC & AI Infrastructure: Architect cloud-native and hybrid solutions for compute intens

Full-time

USD 150,289.00 - 171,674.00 per year

Senior ML Infrastructure Engineer (Compute)

Remote or Sunnyvale, California

•

Today

Job Description About the Team: The AI Validation Platform team owns the cloud-agnostic, reliable, and cost-efficient platform that powers GM's AV efforts. We're proud to serve as the infrastructure platform for teams developing autonomous vehicles (L3/L4/L5). Our platform supports the simulated validation of state-of-the-art (SOTA) machine learning models, with a focus on performance, availability, concurrency, and scalability. We enable rapid innovation and development by prioritizing high-im

Full-time

Senior ML Accelerator Engineer - GPU

Remote or Sunnyvale, California

•

Today

Job Description About the Mission GM's vision of Zero Crashes, Zero Emissions, and Zero Congestion guides everything we do in autonomous and assisted driving. The AV organization is building advanced automated driving technologies, including Level 4-capable fully self-driving systems, to move us toward safer, more sustainable, and more accessible mobility. For the AI Kernels & Compilers team, that mission shows up in the details: turning cutting-edge perception, prediction, and planning researc

Full-time

USD 128,700.00 - 261,300.00 per year

Staff ML Infrastructure Engineer (Compute)

Remote or Sunnyvale, California

•

Today

Full-time

USD 197,000.00 - 326,000.00 per year

Hardware Engineer - Connectivity Modules

Remote or Mountain View, California

•

Today

Job Description Senior Hardware Engineer: Connectivity Modules (Validation/Testing) Hybrid: This role is categorized as hybrid. This means the successful candidate is expected to report to one of the following locations: Warren, MI, or Sunnyvale, CA three times (Tues., Wed., Thurs.) per week, at minimum. The Ideal Candidate: Connectivity plays a pivotal role in using and advancing technology to offer unparalleled customer experience and develop revenue generating streams while acting as a co

Full-time

USD 113,900.00 - 174,800.00 per year

Storage Architect / Senior Storage Systems Administrator (Research & HPC Data Platforms)

Stanford, California

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Today

Reports to: Research & HPC Data Platforms Team Lead Please note: Visa Sponsorship is not provided for this position. The Opportunity Stanford's Research Computing team is seeking a storage expert to join our Research & HPC Data Platforms group. This is a flexible-level posting; we are seeking either a Storage Architect or a Senior Storage Systems Administrator to maintain and expand our current world-class infrastructure. You will work directly with our research and HPC data platforms team lea

Full-time

USD 150,289.00 - 171,674.00 per year

Senior AI/ML Capacity and Performance Engineer

Remote or Sunnyvale, California

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Today

Job Description About Us: The AV Infrastructure org provides developer environments, cloud infrastructure, and ML/AI GPU platforms for AV research and development teams to build, test, and run faster in GM. The Role: GM is looking for a Senior Performance Engineer to join the AV Capacity and Performance Engineering team in the AV Infrastructure org to support our critical efforts in developing autonomous vehicles. The mission of the AVCPE team is to provide input into large scale ML infrastruct

Full-time

USD 144,700.00 - 261,300.00 per year

Staff Hardware Engineer: Connectivity Modules

Remote or Sunnyvale, California

•

Today

Job Description Hybrid: This role is categorized as hybrid. This means the successful candidate is expected to report to one of the following locations: Warren, MI or Sunnyvale, CA three times (Tues., Wed., Thurs.) per week, at minimum. The Ideal Candidate Connectivity plays a pivotal role in using and advancing technology to offer unparalleled customer experience and develop revenue-generating streams, while acting as a cornerstone to offer safety-critical, hands-free driving solutions in li

Full-time

USD 145,000.00 - 222,200.00 per year

Sr. Software Engineer, ML Platform, tvScientific

Remote or San Francisco, California

•

Today

About Pinterest: Millions of people around the world come to our platform to find creative ideas, dream about new possibilities and plan for memories that will last a lifetime. At Pinterest, we're on a mission to bring everyone the inspiration to create a life they love, and that starts with the people behind the product. Discover a career where you ignite innovation for millions, transform passion into growth opportunities, celebrate each other's unique experiences and embrace the flexibility

Full-time

USD 155,584.00 - 320,320.00 per year

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High Performance Computing jobs in San Francisco, CA, USA