Senior Scientist

Hybrid in San Francisco, CA, US • Posted 9 hours ago • Updated 9 hours ago
Contract W2
No Travel Required
Hybrid
$80 - $90/hr
Fitment

Dice Job Match Score™

🛠️ Calibrating flux capacitors...

Job Details

Skills

  • QSAR

Summary

Job Title: Senior Scientist
Location: 201 Haskins Way, South San Francisco, CA 94080

(Hybrid; Remote considered case-by-case)
Pay rate: $80 - $90/hr

 

Overview:
We are seeking a highly motivated Cheminformatics Scientist to design and build end-to-end small molecule computational workflows within the TuneLab platform. This role spans the drug discovery pipeline, from virtual screening to lead optimization, combining cheminformatics, physics-based modeling, and machine learning.

Key Responsibilities:

  • Design and implement workflows for virtual screening, hit identification, and lead optimization
  • Apply computational chemistry methods including QSAR, docking, molecular dynamics (MD), and FEP
  • Perform ultra-large library searches (substructure, similarity, pharmacophore)
  • Develop molecular enumeration strategies (reaction- and fragment-based)
  • Collaborate with ML and engineering teams to deploy scalable workflows
  • Evaluate tools and make build-vs-buy decisions

Required Qualifications:

  • MS or PhD in Cheminformatics, Computational Chemistry, or related field
  • Strong experience in small molecule drug discovery workflows
  • Expertise in cheminformatics and modeling techniques (QSAR, docking, similarity search, etc.)
  • Hands-on experience with RDKit, OpenEye, or similar tools
  • Proficiency in Python

Preferred Qualifications:

  • Experience with large chemical libraries (e.g., Enamine REAL)
  • Knowledge of generative chemistry models
  • Experience integrating ML into production workflows
  • Familiarity with workflow tools like Airflow or Nextflow

 

 

Employers have access to artificial intelligence language tools (“AI”) that help generate and enhance job descriptions and AI may have been used to create this description. The position description has been reviewed for accuracy and Dice believes it to correctly reflect the job opportunity.
  • Dice Id: realsoft
  • Position Id: 8938215
  • Posted 9 hours ago
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